Schoevers R A, Geerlings M I, Beekman A T, Penninx B W, Deeg D J, Jonker C, Van Tilburg W
Department of Psychiatry, Vrije Universiteit Amsterdam, Valeriusplein 9, 1075 BG Amsterdam, The Netherlands.
Br J Psychiatry. 2000 Oct;177:336-42. doi: 10.1192/bjp.177.4.336.
The association between depression and increased mortality risk in older persons may depend on the severity of the depressive disorder and gender.
To investigate the association between major and mild depressive syndromes and excess mortality in community-living elderly men and women.
Depression (Geriatric Mental State AGECAT) was assessed in 4051 older persons, with a 6-year follow-up of community death registers. The mortality risk of neurotic and psychotic depression was calculated after adjustment for demographic variables, physical illness, cognitive decline and functional disabilities.
A total of 75% of men and 41% of women with psychotic depression had diet at follow-up. Psychotic depression was associated with significant excess mortality in both men and women. Neurotic depression was associated with a 1.67-fold higher mortality risk in men only.
In the elderly, major depressive syndromes increase the risk of death in both men and women, but mild depression increases the risk of death only in men.
老年人中抑郁症与死亡风险增加之间的关联可能取决于抑郁症的严重程度和性别。
调查社区居住的老年男性和女性中重度和轻度抑郁综合征与额外死亡率之间的关联。
对4051名老年人进行抑郁症评估（老年精神状态AGECAT），并对社区死亡登记册进行6年随访。在对人口统计学变量、身体疾病、认知衰退和功能残疾进行调整后，计算神经症性和精神病性抑郁症的死亡风险。
患有精神病性抑郁症的男性中有75%以及女性中有41%在随访时有死亡情况。精神病性抑郁症在男性和女性中均与显著的额外死亡率相关。仅神经症性抑郁症在男性中与死亡风险高1.67倍相关。
在老年人中，重度抑郁综合征会增加男性和女性的死亡风险，但轻度抑郁症仅会增加男性的死亡风险。
