含有6-氨基-6-脱氧呋喃糖部分的卡那霉素A类似物的合成。

Synthesis of kanamycin A analogs containing a 6-amino-6-deoxyglycofuranose moiety.

作者信息

Kobayashi Y, Ohgami T, Ohtsuki K, Tsuchiya T

机构信息

Institute of Bioorganic Chemistry, Kawasaki, Japan.

出版信息

Carbohydr Res. 2000 Nov 3;329(2):325-40. doi: 10.1016/s0008-6215(00)00184-1.

DOI:10.1016/s0008-6215(00)00184-1

PMID:11117316

Abstract

Three kanamycin A analogs containing 6-amino-6-deoxyglycofuranoses have been prepared as candidates for potential activity against resistant bacteria producing 6'-N-acetyltransferase. They are 4-O-(6-amino-3,5,6-trideoxy-alpha-D-, -beta-D-, and -beta-L-erythro -hexofuranosyl)-6-O-(3-amino-3-deoxy-alpha-D-glucopyranosyl)-2,5-dideoxy-5-epi-5-fluorostreptamine. Structure-activity relationships of these compounds are discussed.

摘要

已制备出三种含有6-氨基-6-脱氧糖呋喃糖的卡那霉素A类似物，作为对抗产生6'-N-乙酰基转移酶的耐药细菌具有潜在活性的候选物。它们是4-O-(6-氨基-3,5,6-三脱氧-α-D-、-β-D-和-β-L-赤藓糖基)-6-O-(3-氨基-3-脱氧-α-D-吡喃葡萄糖基)-2,5-二脱氧-5-表-5-氟链霉胺。讨论了这些化合物的构效关系。