大鼠脑不同区域对促甲状腺激素释放激素失活作用的年龄依赖性变化

Age-dependent changes in the inactivation of thyrotrophin-releasing hormone by different areas of rat brain.

作者信息

Griffiths E C, White N, Jeffcoate S L

出版信息

Neurosci Lett. 1979 Jun;13(1):57-62. doi: 10.1016/0304-3940(79)90075-2.

Abstract

Age-dependent changes in the inactivation of thyrotrophin-releasing hormone (TRH) were investigated in two subcellular fractions prepared from hypothalamus, thalamus, cortex and cerebellum of male rats. It was found that, in both supernatant and particulate fractions from the four brain areas, enzyme activity increased to a peak at 10-25 days of age and then decreased gradually until adult levels were reached. The changes in TRH degradation observed may be related to alterations in hypothalamic TRH content with age and to maturation of the tripeptide's putative neurotransmitter/neuromodulator function.

摘要

在从雄性大鼠的下丘脑、丘脑、皮层和小脑中制备的两个亚细胞组分中，研究了促甲状腺激素释放激素（TRH）失活的年龄依赖性变化。结果发现，在这四个脑区的上清液和颗粒组分中，酶活性在10至25日龄时均增加至峰值，然后逐渐下降，直至达到成年水平。观察到的TRH降解变化可能与下丘脑TRH含量随年龄的变化以及三肽假定的神经递质/神经调节功能的成熟有关。