调节酿酒酵母假菌丝分化的信号转导级联反应。

Signal transduction cascades regulating pseudohyphal differentiation of Saccharomyces cerevisiae.

作者信息

Pan X, Harashima T, Heitman J

机构信息

Department of Genetics, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA.

出版信息

Curr Opin Microbiol. 2000 Dec;3(6):567-72. doi: 10.1016/s1369-5274(00)00142-9.

DOI:10.1016/s1369-5274(00)00142-9

PMID:11121775

Abstract

In response to nitrogen limitation, diploid cells of the yeast Saccharomyces cerevisiae undergo a dimorphic transition to filamentous pseudohyphal growth. At least two signaling pathways regulate filamentation. One involves components of the MAP kinase cascade that also regulates mating of haploid cells. The second involves a nutrient-sensing G-protein-coupled receptor that signals via an unusual G(alpha) protein, cAMP and protein kinase A. Recent studies reveal crosstalk between these pathways during pseudohyphal growth. Related MAP kinase and cAMP pathways regulate filamentation and virulence of human and plant fungal pathogens, and represent novel targets for antifungal drug design.

摘要

为响应氮限制，酿酒酵母的二倍体细胞会经历双态转变，形成丝状假菌丝生长。至少有两条信号通路调控丝状化过程。一条通路涉及丝裂原活化蛋白激酶（MAP激酶）级联反应的组分，该级联反应也调控单倍体细胞的交配过程。另一条通路涉及一种营养感应型G蛋白偶联受体，它通过一种特殊的Gα蛋白、环磷酸腺苷（cAMP）和蛋白激酶A进行信号传导。最近的研究揭示了在假菌丝生长过程中这些通路之间存在相互作用。相关的MAP激酶和cAMP通路调控人类和植物真菌病原体的丝状化和毒力，是抗真菌药物设计的新靶点。