De Silva B, Banney L, Uttley W, Luqmani R, Schofield O
Department of Dermatology, Royal Infirmary of Edinburgh, and Department of Paediatric Rheumatology, Royal Hospital for Sick Children, Edinburgh, Scotland. BDeS2.excite.com
Pediatr Dermatol. 2000 Nov-Dec;17(6):480-3. doi: 10.1046/j.1525-1470.2000.01827.x.
Pseudoporphyria is characterized by erythema, blistering, and scarring on sun-exposed skin. Nonsteroidal antiinflammatory drugs (NSAIDs) are implicated in the etiology of this condition. In a 1-year prospective study of children attending the pediatric rheumatology clinic in Edinburgh we found a prevalence of pseudoporphyria of 10.9% in children taking NSAIDs for juvenile idiopathic arthritis. Naproxen was the most commonly implicated NSAID, independent of dosage. Blue/gray eye color was an independent risk factor for the development of pseudoporphyria. We would advise caution in prescribing naproxen in these children to prevent disfiguring facial scarring.
假性卟啉病的特征是暴露于阳光下的皮肤出现红斑、水疱和瘢痕形成。非甾体抗炎药（NSAIDs）与这种疾病的病因有关。在一项针对爱丁堡儿科风湿病诊所就诊儿童的为期1年的前瞻性研究中，我们发现服用NSAIDs治疗幼年特发性关节炎的儿童中假性卟啉病的患病率为10.9%。萘普生是最常涉及的NSAID，与剂量无关。蓝/灰色眼睛颜色是假性卟啉病发生的独立危险因素。我们建议在这些儿童中谨慎开具萘普生处方，以防止面部出现毁容性瘢痕。
