Sansur C A, Chin L S, Ames J W, Banegura A T, Aggarwal S, Ballesteros M, Amin P, Simard J M, Eisenberg H
Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201-1595, USA.
Stereotact Funct Neurosurg. 2000;74(1):37-51. doi: 10.1159/000056462.
One hundred and ninety-three patients with brain metastases from various primary sites received Gamma Knife radiosurgery (GKR) from July 1992 to August 1997 and were reviewed to evaluate their clinical outcome. Survival follow-up was available on 173 patients. Whole-brain radiation therapy was also administered to 148 of these patients. The median survival was 13.1 months from initial detection of brain metastases, and 7.5 months from GKR. Univariate and multivariate analyses were performed to determine prognostic factors that influenced survival following GKR. Enhanced survival is observed in patients with radiosensitive tumor types, supratentorial tumor, history of brain tumor resection, controlled primary site, and absent extracranial metastases. Local lesion control was obtained in 82% of the patients according to their last follow-up MRI scan. GKR is an effective means of treating patients with brain metastases.
1992年7月至1997年8月，193例来自不同原发部位的脑转移瘤患者接受了伽玛刀放射外科治疗（GKR），并对其临床结果进行了回顾性评估。173例患者有生存随访数据。其中148例患者还接受了全脑放射治疗。从最初发现脑转移瘤起，中位生存期为13.1个月，从接受GKR起为7.5个月。进行单因素和多因素分析以确定影响GKR后生存的预后因素。在肿瘤类型对放疗敏感、幕上肿瘤、有脑肿瘤切除史、原发部位得到控制且无颅外转移的患者中观察到生存期延长。根据最后一次随访的MRI扫描结果，82%的患者实现了局部病灶控制。GKR是治疗脑转移瘤患者的有效手段。
