胶囊中群多普利的高效液相色谱测定法。
High-performance liquid chromatographic assay of trandolapril in capsules.
作者信息
Gumieniczek A, Hopkała H
机构信息
Department of Medicinal Chemistry, Medical Academy 6 Chodźki Str., 20-093 Lublin, Poland.
出版信息
Acta Pol Pharm. 2000 Jul-Aug;57(4):253-5.
Rapid, simple and accurate chromatographic (HPLC) method for the determination of trandolapril was elaborated. Samples were chromatographed on a LiChrosorb RP-18 column and the mobile phase was acetonitrile -0.067 M phosphate buffer pH 2.7 (7:3, v/v). The UV detection at 220 nm and benazepril as an internal standard were used. The method was tested for linearity (over the range 4-20 micrograms.ml-1), precision and accuracy and was successfully applied for the quantitative determination of trandolapril in capsules.
建立了一种快速、简便且准确的用于测定群多普利的色谱法（高效液相色谱法）。样品在LiChrosorb RP - 18柱上进行色谱分离，流动相为乙腈 - 0.067 M pH 2.7的磷酸盐缓冲液（7:3，v/v）。采用在220 nm处的紫外检测，并以贝那普利作为内标。对该方法进行了线性（在4 - 20微克·毫升⁻¹范围内）、精密度和准确度测试，并成功应用于胶囊中群多普利的定量测定。
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