Faulkner L C
J Am Vet Med Assoc. 1975 Mar 1;166(5):479-80.
Testicular, thyroidal, and adrenal activities were measured in male Beagles immunized against bovine luteinizing hormone for 15 or 52 weeks. Circulating antibodies were associated with atrophy of the testes, epididymides, and prostate gland. The effects of immunization were apparent by high amounts of antibodies and by reproductive dysfunction for as long as a year in 3 of 4 dogs. The thyroid and adrenal glands were not detectably affected. A single dose of human chorionic gonadotropin stimulated production of antibodies that failed to cross react with canine gonadotropins or to cause reproductive failure in immunized dogs. A single dose of ovine gonadotropin stimulated production of antibodies that were associated with inability to ejaculate for more than 20 weeks.
对雄性比格犬进行长达15周或52周的抗牛促黄体激素免疫，测定其睾丸、甲状腺和肾上腺的活性。循环抗体与睾丸、附睾和前列腺的萎缩有关。在4只犬中有3只，通过高含量的抗体以及长达一年的生殖功能障碍，可明显看出免疫的影响。甲状腺和肾上腺未检测到明显影响。单剂量的人绒毛膜促性腺激素刺激产生的抗体，不会与犬促性腺激素发生交叉反应，也不会导致免疫犬出现生殖功能衰竭。单剂量的羊促性腺激素刺激产生的抗体，与免疫犬超过20周无法射精有关。
