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Resolution of DL-hydantoins by D-hydantoinase from Vigna angularis: production of highly enantioenriched N-carbamoyl-D-phenylglycine at 100% conversion.

作者信息

Arcuri M B, Antunes O A, Sabino S J, Pinto G F, Oestreicher E G

机构信息

Instituto de Química, Universidade Federal do Rio de Janeiro, Centro de Tecnologia, RJ, Brasil.

出版信息

Amino Acids. 2000;19(2):477-82. doi: 10.1007/s007260070025.

DOI:10.1007/s007260070025
PMID:11128554
Abstract

D-Hydantoinase from Vigna angularis hydrolyzed rac-5-monosubstituted-hydantoins with polar and aromatic side chains and dihydrothymine but rac-5,5-disubstituted-hydantoins were not substrates of this enzyme. 5-Phenylhydantoin was the best substrate. By using this substrate, Ncarbamoyl-D-phenylglycine was obtained in quantitative yield and over 98% ee.

摘要

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