Suppr超能文献

机械瓣膜置换术后患者使用低分子肝素抗凝的并发症。病例报告。

A complication in anticoagulation using low-molecular weight heparin in a patient with a mechanical valve prosthesis. A case report.

作者信息

Berndt N, Khan I, Gallo R

机构信息

Cardiac Services Department, Armed Forces Hospital, Southern Region Khamis Mushayt, Saudi Arabia.

出版信息

J Heart Valve Dis. 2000 Nov;9(6):844-6.

Abstract

All mechanical heart valves are thrombogenic, and are associated with thromboembolic complications becomes ineffective. when anticoagulation Controversy exists with regard to the appropriate and safe anticoagulation regimen of gravid women with mechanical heart valve prostheses. While oral anticoagulants such as warfarin may be associated with fetal complications, the role of low-molecular weight heparin (LMWH) and heparinoids (and their respective appropriate dosage) have still to be determined. In developing countries such as Saudi Arabia, the prevalence of rheumatic fever is high, as is the percentage of female patients with mechanical heart valves and who are of child-bearing age. Thus, the issue of adequate anticoagulation on one hand, and avoidance of warfarin-induced embryopathy on the other hand, is crucial. To date, few reports are available of LMWH as sole anticoagulant in patients with mechanical heart valves. We report a case of massive valve thrombosis with subsequent pulmonary edema after warfarin anticoagulation was changed to LMWH during pregnancy, and administered at too low a dose.

摘要

所有机械心脏瓣膜都具有血栓形成性,并且与血栓栓塞并发症相关。当抗凝治疗无效时,对于患有机械心脏瓣膜假体的妊娠妇女,合适且安全的抗凝方案存在争议。虽然口服抗凝剂如华法林可能与胎儿并发症有关,但低分子量肝素(LMWH)和类肝素(及其各自合适的剂量)的作用仍有待确定。在沙特阿拉伯等发展中国家,风湿热的患病率很高,患有机械心脏瓣膜且处于育龄期的女性患者比例也很高。因此,一方面要进行充分抗凝,另一方面要避免华法林引起的胚胎病,这一问题至关重要。迄今为止,关于LMWH作为机械心脏瓣膜患者唯一抗凝剂的报道很少。我们报告了一例在妊娠期间将华法林抗凝改为LMWH并以过低剂量给药后发生大量瓣膜血栓形成并随后出现肺水肿的病例。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验