Hall S F, Groome P A, Rothwell D
Department of Otolaryngology, Queen's University, Kingston, Ontario, Canada.
Laryngoscope. 2000 Dec;110(12):2041-6. doi: 10.1097/00005537-200012000-00012.
To identify patterns and predictors of relapse and to determine whether the time to relapse influences survival.
Multivariate anal. ysis of prospective database.
We present findings in 446 consecutive prospective patients from a regional cancer center with invasive squamous cell carcinoma who were treated for cure and were declared disease free. Time to relapse, site of relapse, and survival are reported by stage and site using bivariate and multivariate analysis.
Thirty-six percent of patients relapsed. The median time to relapse was 8.3 months, and 95% of relapses occurred within 3 years. T stage in the TNM staging system was associated with relapse, and N stage was not. In patients who relapsed before the median time to relapse, prognosis was worse than in those who relapsed after that time.
确定复发模式及预测因素，并确定复发时间是否影响生存率。
对前瞻性数据库进行多变量分析。
我们报告了来自一个地区癌症中心的446例连续前瞻性患者的研究结果，这些患者患有浸润性鳞状细胞癌，接受了根治性治疗并被宣布无疾病。通过双变量和多变量分析，按分期和部位报告复发时间、复发部位和生存率。
36%的患者复发。复发的中位时间为8.3个月，95%的复发发生在3年内。TNM分期系统中的T分期与复发相关，而N分期与复发无关。在复发时间中位数之前复发的患者，其预后比在该时间之后复发的患者更差。
