Ewart F G, Cutler M G
Psychopharmacology (Berl). 1979 Apr 25;62(3):247-51. doi: 10.1007/BF00431955.
Behavioural and developmental effects of exposure to a low level of ethyl alcohol from conception to adulthood have been examined in mice. A 5% solution of alcohol in the drinking fluid of male and female adults did not impair fertility. The offspring of treated mice were significantly lighter at birth than their controls and remained so throughout their life span. No congenital malformations were observed. Behaviour of the offspring 3--4 weeks of age and in adulthood was examined by ethological analysis of encounters between alcohol-treated and control mice of the same sex. In male and female juvenile mice receiving 5% alcohol, the frequency and duration of social investigation were significantly lower than those of control partners and the duration of non-social behaviour was raised. Individual elements of 'investigate' and 'sniff' were significantly reduced in frequency. In alcohol-treated adults, the only behavioural difference from controls was an increased frequency of flight elements occurring in males. It is suggested that long-term exposure to alcohol may lead to behavioural adaptation.
对小鼠从受孕到成年期接触低水平乙醇的行为和发育影响进行了研究。成年雄性和雌性小鼠饮用含5%酒精的溶液并未损害生育能力。经处理的小鼠后代出生时明显比对照组轻，且在其整个寿命期内一直如此。未观察到先天性畸形。通过对同性经酒精处理的小鼠和对照小鼠之间的相遇进行行为学分析，研究了3 - 4周龄和成年后代的行为。在接受5%酒精的雄性和雌性幼年小鼠中，社交探究的频率和持续时间显著低于对照伙伴，非社交行为的持续时间增加。“探究”和“嗅闻”的个别元素频率显著降低。在经酒精处理的成年小鼠中，与对照组唯一的行为差异是雄性中逃跑元素的频率增加。提示长期接触酒精可能导致行为适应。
