Chapman J B, Cutler M G
Psychopharmacology (Berl). 1983;79(2-3):155-60. doi: 10.1007/BF00427803.
Phenobarbitone at a concentration of 187.5 mg/l in drinking fluid of breeding mice and their offspring after weaning did not affect gestation period, litter size, litter weight or pup development before weaning, although a slight retardation of weight gain after weaning occurred. This level of phenobarbitone given to mice after weaning did not affect weight gain. The average daily intake of phenobarbitone ranged from 30 to 52 mg/kg body weight depending on age and sex. Behaviour of offspring and mice treated after weaning was examined by ethological analysis of encounters between unfamiliar mice of the same sex and treatment group in a neutral enclosure. After lifelong exposure to phenobarbitone mice at 5 and 15 weeks of age showed an increased amount of scanning and exploration of the unfamiliar cage coupled with a decrease of time spent in immobility. Difference from control levels was more pronounced at 15 than at 5 weeks of age, in part because controls showed more immobility and explored less as they matured. No behavioural changes were detected in mice treated with this level of phenobarbitone after weaning. Lifelong exposure to phenobarbitone did not affect agonistic behaviour in pair-housed males at 30 weeks of age, and under these circumstances no longer stimulated exploration to a significant extent.
在繁殖小鼠及其断奶后后代的饮用水中加入浓度为187.5毫克/升的苯巴比妥，虽断奶后体重增加略有迟缓，但对妊娠期、窝仔数、窝仔体重或断奶前仔鼠发育并无影响。给断奶后的小鼠投喂此水平的苯巴比妥对体重增加没有影响。根据年龄和性别，苯巴比妥的日均摄入量为30至52毫克/千克体重。通过对处于中性环境中的相同性别和处理组的陌生小鼠之间的相遇进行行为学分析，研究断奶后处理的后代和小鼠的行为。在终身接触苯巴比妥后，5周龄和15周龄的小鼠对陌生笼子的扫描和探索行为增加，同时静止不动的时间减少。与对照水平的差异在15周龄时比5周龄时更为明显，部分原因是随着对照组小鼠成熟，它们表现出更多的静止不动且探索行为更少。断奶后用此水平的苯巴比妥处理的小鼠未检测到行为变化。终身接触苯巴比妥对30周龄成对饲养的雄性小鼠的攻击行为没有影响，在这种情况下，也不再在很大程度上刺激探索行为。
