Goriya Y, Hoshi M, Etani N, Kimura K, Shichiri M
J Nucl Med. 1975 Apr;16(4):270-4.
A dynamic study of scintigraphy of the pancreas using 75Se-selenomethionine in diabetic patients was performed. Patients were selected who complained of abdominal pain or diarrhea or both and whose pancreatic exocrine functions were thought to be disturbed. Selenium-75-selenomethionine (3 muCi/kg body weight) was injected intravenously and radioactivity (cpm) was recorded by a scinticamera for 10 min successively up to 120 min. After 20-30 min the increase of radioactivity in the selected area of the displayed pancreas usually reached a plateau. Pancreozymin (1 Harper unit/kg) and secretin (1 harper unit/kg) were administered intravenously and decrease of radioactivity in the same area was followed for 60 min to examine pancreatic exocrine function. After 75Se-selenomethionine injection, the angle of the initial increase of radioactivity, the height of the plateau, and the reactive decrease of radioactivity after pancreozymin and secretin were analyzed in each case. Radioactivity recorded on data tape was reproduced for each 10-min period on a cathode-ray tube display. Areas of interest were selected for dynamic analyses. To supplement the diagnosis by visual image of a scintigram of the pancreas, the scintigram was quantified in the present study and the dynamic curves of radioactivity in the selected area of the displayed pancreas were studied for a total of 3 hr. Application of the dynamic study of the pancreas scintigraphy and the additional data analyses seemed useful for the early detection of pancreatic exocrine dysfunction in diabetic patients in whom the ordinary laboratory pancreatic exocrine function tests gave uncertain results.
对糖尿病患者使用75Se-硒代蛋氨酸进行胰腺闪烁扫描的动态研究。选择主诉腹痛或腹泻或两者皆有的患者，且其胰腺外分泌功能被认为受到干扰。静脉注射75-硒代蛋氨酸（3微居里/千克体重），并用闪烁照相机连续记录放射性（每分钟计数），直至120分钟，每10分钟记录一次。20-30分钟后，所显示胰腺选定区域的放射性增加通常达到平台期。静脉注射胰酶泌素（1哈珀单位/千克）和促胰液素（1哈珀单位/千克），然后在同一区域跟踪放射性降低情况60分钟，以检查胰腺外分泌功能。在注射75Se-硒代蛋氨酸后，分析每种情况下放射性最初增加的角度、平台期高度以及胰酶泌素和促胰液素后放射性的反应性降低情况。数据带上记录的放射性在阴极射线管显示器上每10分钟重现一次。选择感兴趣区域进行动态分析。为了补充通过胰腺闪烁图视觉图像进行的诊断，本研究对闪烁图进行了量化，并研究了所显示胰腺选定区域放射性的动态曲线，共3小时。胰腺闪烁扫描的动态研究及额外的数据分析应用，对于普通实验室胰腺外分泌功能检查结果不确定的糖尿病患者早期发现胰腺外分泌功能障碍似乎是有用的。
