Stadnicki S S, Lin F S, Allen J R
Res Commun Chem Pathol Pharmacol. 1979 May;24(2):313-27.
Polychlorinated biphenyls (PCBs) are widespread environmental pollutants which have been shown to be carcinogenic. One possible mechanism for the apparent carcinogenicity of PCBs is their metabolism to phenolic metabolites through an arene oxide intermediate, with the arene oxide that is formed being the ultimate mutagenic or carcinogenic species. The ability of a tetrachlorobiphenyl and its phenolic and arene oxide metabolites to cause single strand breaks in DNA was therefore examined. 2,2',5,5'-TCB-3,4-epoxide was more potent in causing DNA single strand breaks than either 2,2',5,5'-TCB or a mixture of 3-hydroxy and 4-hydroxy-2,2',5,5'-TCB. These results support the idea that PCB epoxide may be involved in PCB carcinogenesis.
多氯联苯（PCBs）是广泛存在的环境污染物，已被证明具有致癌性。PCBs明显致癌性的一种可能机制是它们通过环氧芳烃中间体代谢为酚类代谢产物，形成的环氧芳烃是最终的诱变或致癌物质。因此，研究了一种四氯联苯及其酚类和环氧芳烃代谢产物导致DNA单链断裂的能力。2,2',5,5'-四氯联苯-3,4-环氧化物在导致DNA单链断裂方面比2,2',5,5'-四氯联苯或3-羟基和4-羟基-2,2',5,5'-四氯联苯的混合物更有效。这些结果支持了PCB环氧化物可能参与PCB致癌过程的观点。
