Stockamp K
J Urol. 1975 Jan;113(1):128-31. doi: 10.1016/s0022-5347(17)59425-2.
Five children in whom reflux and progressive hydronephrosis persisted despite multiple surgical attempts or repair are described. In all cases cystomanometry displayed a marked elevation of the bladder outlet resistance combined with high intravesical pressure values. Therapy with phenoxybenzamine, an alpha-adrenergic blocker, was successful in all cases, restoring a free urine passage of the upper urinary tract and unimpaired voiding preventing urinary diversion which has been considered in some of these children. Although there were no signs of bladder neuropathy, a hyperfunction of the sympathetic innervation as acause for bladder complications is discussed.
本文描述了5名儿童，尽管多次尝试手术修复，但反流和进行性肾积水仍持续存在。在所有病例中，膀胱测压显示膀胱出口阻力显著升高，同时膀胱内压值也很高。使用α-肾上腺素能阻滞剂苯氧苄胺进行治疗在所有病例中均取得成功，恢复了上尿路的自由尿液通过，排尿正常，避免了这些儿童中部分人曾考虑过的尿流改道。尽管没有膀胱神经病变的迹象，但仍讨论了交感神经支配功能亢进作为膀胱并发症原因的可能性。
