肺炎链球菌NADH氧化酶介导的能力调节涉及信号转导。
Competence modulation by the NADH oxidase of Streptococcus pneumoniae involves signal transduction.
作者信息
Echenique J R, Trombe M C
机构信息
Laboratoire de Genétique et Physiologie Bactérienne, Centre Hospitalo Universitaire de Rangueil, Université Paul Sabatier, 31403 Toulouse Cedex, France.
出版信息
J Bacteriol. 2001 Jan;183(2):768-72. doi: 10.1128/JB.183.2.768-772.2001.
Abstract
Oxygen controls competence development in Streptococcus pneumoniae. Oxygen signaling involves the two-component signal transduction systems CiaRH and ComDE and the competence-stimulating peptide encoded by comC and processed by ComAB. We found that NADH oxidase (Nox) was required for optimal competence. Transcriptional analysis and genetic dissection showed that Nox was involved in post-transcriptional activation of the response regulator ComE and in the transcriptional control of ciaRH and comCDE. Thus, in S. pneumoniae, Nox, with O(2) as its secondary substrate, is part of the O(2)-signaling pathway.
摘要
氧气控制肺炎链球菌感受态的发育。氧气信号传导涉及双组分信号转导系统CiaRH和ComDE以及由comC编码并由ComAB加工的感受态刺激肽。我们发现NADH氧化酶（Nox）是最佳感受态所必需的。转录分析和基因剖析表明，Nox参与应答调节因子ComE的转录后激活以及ciaRH和comCDE的转录控制。因此，在肺炎链球菌中，以O(2)作为第二底物的Nox是O(2)信号通路的一部分。
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