Salvesen R, Bekkelund S I
Department of Neurology, University of Tromsø, Bodø, Norway.
Headache. 2000 Nov-Dec;40(10):824-9. doi: 10.1046/j.1526-4610.2000.00149.x.
To investigate potential seasonal variation of migraine and other headaches in an Arctic population where light conditions are extreme during both winter and summer.
Due to the immense seasonal variation in sunlight, focus on seasonal migraine variation in a population living in an Arctic area is interesting even from a theoretical point of view.
Northern Norway comprises the three Norwegian counties north of the Arctic Circle. There are three neurology centers in this region, which provide service for approximately half a million people. During a 2-year period, 1403 patients (0.3% of the population) were referred to these centers for a specialist assessment of their headache. A questionnaire was mailed to all these patients; the questionnaire included questions on headache characteristics to make it possible to identify migraine according to the International Headache Society criteria. Questions on seasonal variation of headache were also included.
One thousand fifty-two patients (75%) returned the questionnaire. Nineteen percent reported that their headaches clearly did vary with season; 11% experienced more headache during polar night, while 7% had more symptoms during midnight sun season. When the migraine and nonmigraine groups were compared, significant differences were demonstrated. Patients with nonmigrainous headache were more likely to have increased headaches during the dark winter season, while patients with migraine experienced more headache during the summer (P =.002).
Patients with migraine were more likely to have headache during the bright Arctic summer season, and this distinguishes migraine from other headaches in this study. This observation may pertain to the increased light sensitivity and recently demonstrated cortical hyperexcitability in patients with migraine, and may perhaps suggest a role of the hypothalamus and/or melatonin secretion in migraine pathophysiology.
在一个冬季和夏季光照条件都极为极端的北极人群中，调查偏头痛及其他头痛潜在的季节性变化。
由于阳光存在巨大的季节性变化，即使从理论角度来看，关注北极地区人群的季节性偏头痛变化也很有意思。
挪威北部包括北极圈以北的三个挪威郡。该地区有三个神经学中心，为大约50万人提供服务。在两年期间，1403名患者（占人口的0.3%）被转诊至这些中心进行头痛的专科评估。向所有这些患者邮寄了一份问卷；问卷包括有关头痛特征的问题，以便能够根据国际头痛协会的标准识别偏头痛。还包括有关头痛季节性变化的问题。
1052名患者（75%）返回了问卷。19%的患者报告其头痛明显随季节变化；11%的患者在极夜期间头痛加剧，而7%的患者在极昼季节症状更多。比较偏头痛组和非偏头痛组时，发现了显著差异。非偏头痛性头痛患者在黑暗的冬季更易出现头痛加剧，而偏头痛患者在夏季头痛更多（P = 0.002）。
在北极明亮的夏季，偏头痛患者更易出现头痛，在本研究中这将偏头痛与其他头痛区分开来。这一观察结果可能与偏头痛患者光敏感性增加以及最近显示的皮质兴奋性过高有关，并且可能提示下丘脑和/或褪黑素分泌在偏头痛病理生理学中的作用。
Zotero 插件