Kay M A, Glorioso J C, Naldini L
Departments of Pediatrics and Genetics, Stanford University, Stanford, CA, USA.
Nat Med. 2001 Jan;7(1):33-40. doi: 10.1038/83324.
Considered by some to be among the simpler forms of life, viruses represent highly evolved natural vectors for the transfer of foreign genetic information into cells. This attribute has led to extensive attempts to engineer recombinant viral vectors for the delivery of therapeutic genes into diseased tissues. While substantial progress has been made, and some clinical successes are over the horizon, further vector refinement and/or development is required before gene therapy will become standard care for any individual disorder.
病毒被一些人认为是较为简单的生命形式之一，它是将外源遗传信息导入细胞的高度进化的天然载体。这一特性促使人们广泛尝试构建重组病毒载体，以便将治疗性基因导入患病组织。虽然已取得了重大进展，一些临床成功也指日可待，但在基因治疗成为任何一种疾病的标准治疗方法之前，还需要进一步优化和/或开发载体。
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