Tan Peng H, Tan Peck L, George Andrew J T, Chan Christopher L H
Oxford Transplant Centre, Oxford Radcliffe Hospitals NHS Trust, Oxford University, Churchill Hospital, Old Road, Oxford, OX3 7LJ, UK.
Expert Opin Biol Ther. 2006 Aug;6(8):759-72. doi: 10.1517/14712598.6.8.759.
Gene therapy holds promise in preventing the development of many diseases. One of the possible applications is the management of organ transplantation. Over the years, advances in vector development have allowed the clinical progression of this form of therapy to become more attainable. Viral vector technology has proved to be better than non-viral vectors at ferrying therapeutic genes to cells. However, many deficiencies in viral vectors hinder the full realisation of gene-based therapy in transplantation. Here, these deficiencies and their ramifications for the future of viral vector development are fully analysed. The authors propose that the slow progress of gene therapy in transplantation may be related to the deficiencies in viral vectors.
基因治疗在预防多种疾病的发展方面具有前景。其中一个可能的应用是器官移植的管理。多年来，载体开发的进展使这种治疗形式的临床进展变得更可实现。在将治疗性基因运送到细胞方面，病毒载体技术已被证明比非病毒载体更好。然而，病毒载体中的许多缺陷阻碍了基于基因的治疗在移植中的全面实现。在此，对这些缺陷及其对病毒载体开发未来的影响进行了全面分析。作者提出，基因治疗在移植中进展缓慢可能与病毒载体的缺陷有关。
