Kallio M, Haapaniemi T, Turkka J, Suominen K, Tolonen U, Sotaniemi K, Heikkilä V P, Myllylä V
Department of Clinical Neurophysiology, University of Oulu, Oulu, Finland.
Eur J Neurol. 2000 Nov;7(6):667-72. doi: 10.1046/j.1468-1331.2000.00127.x.
The aim of this study was to evaluate cardiovascular responses as a marker of autonomic nervous system (ANS) disturbances in patients with untreated Parkinson's disease (PD) and to assess the relationship between them and the clinical characteristics of PD. The ANS functions were investigated in 50 patients with PD and 55 healthy subjects by measuring standard cardiovascular autonomic reflexes and heart rate variability (HRV) at rest using spectral analysis (the autoregressive model and the fast Fourier transformation), the percentage of the counts of beat-to-beat variation greater than 50 ms and the fractal dimension. Significantly attenuated HRV and deficient blood pressure reaction to tilting were found in the PD patient group. The patients with hypokinesia/rigidity as the initial symptom of PD had a more pronounced HRV deficit than those with tremor onset. Untreated PD patients suffer significant failure in cardiovascular nervous system regulation, and in patients with hypokinesia/rigidity as their initial disease manifestation the risk of this ANS dysfunction is high. However, in the early stages of PD these changes did not reach significance at individual level.
本研究旨在评估未经治疗的帕金森病（PD）患者的心血管反应，以此作为自主神经系统（ANS）紊乱的标志物，并评估这些反应与PD临床特征之间的关系。通过使用频谱分析（自回归模型和快速傅里叶变换）测量静息状态下的标准心血管自主反射和心率变异性（HRV）、逐搏变化大于50毫秒的计数百分比以及分形维数，对50例PD患者和55名健康受试者的ANS功能进行了研究。在PD患者组中发现HRV显著减弱，且对倾斜试验的血压反应不足。以运动减少/强直为PD初始症状的患者，其HRV缺陷比以震颤起病的患者更为明显。未经治疗的PD患者在心血管神经系统调节方面存在显著障碍，对于以运动减少/强直为初始疾病表现的患者，发生这种ANS功能障碍的风险很高。然而，在PD的早期阶段，这些变化在个体水平上并不显著。
