柯里拉京类似醚的抗有丝分裂和细胞生长抑制特性。
Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers.
作者信息
Lawrence N J, Rennison D, Woo M, McGown A T, Hadfield J A
机构信息
Department of Chemistry, UMIST, Manchester, UK.
出版信息
Bioorg Med Chem Lett. 2001 Jan 8;11(1):51-4. doi: 10.1016/s0960-894x(00)00596-5.
Abstract
A series of diarylamines, diaryl and arylbenzyl ethers based on combretastatin A-4 was prepared and evaluated for anticancer activity. 2-Methoxy-5-(3',4',5'-trimethoxyphenoxymethyl)phenol was the most active (IC50, K562 20 nM) and caused significant G2/M cell cycle arrest.
摘要
制备了一系列基于康普他汀A-4的二芳基胺、二芳基醚和芳基苄基醚，并对其抗癌活性进行了评估。2-甲氧基-5-(3',4',5'-三甲氧基苯氧基甲基)苯酚活性最高(IC50，K562 20 nM)，并引起显著的G2/M期细胞周期阻滞。
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