Servicios de Pediatría. Hospital Nuestra Señora del Cristal. Orense.
An Esp Pediatr. 2000 Nov;53(5):431-5.
To assess the factors influencing the antipyretic activity of ibuprofen in children.
Children aged between 1 and 10 years attending the emergency department with a temperature of> 38 degrees C were given one dose of ibuprofen (7 mg/kg). Temperature was recorded before and 30, 60, 90, 120, 180 and 240 min after ibuprofen administration. The influence of age, sex, weight, body surface, nosologic entity, previous antipyretic administration, and the association between physical measurements and temperature evolution were assessed.
A total of 384 children were studied. Baseline temperatures were between 38 degrees C and 42 degrees C (mean: 39.1 +/- 60.6). Most of the patients (77.8%) had been feverish for more than 6 hours and 59.5% had received antipyretic treatment. In 93.5% of the children temperature was lowered to 37.5 degrees C or less. In 80.2% of the children this temperature was reached 12 hours after treatment. In 95% of ther children a decrease of at least 1 degree C was achieved. Older age (OR 1.67; 95% CI: 1.032.7), smaller body surface (OR 0.004; 95% CI 00.89) and lower baseline temperature (OR 0.008; 95%CI 00.14) were associated with a smaller antipyretic response (decrease in body temperature lower than 1 degree C).
Ibuprofen is effective in the treatment of fever in children. Its effectiveness is related to age, the degree of fever and body surface.
评估影响布洛芬对儿童退热活性的因素。
年龄在1至10岁、因体温>38摄氏度到急诊科就诊的儿童给予一剂布洛芬（7毫克/千克）。在给予布洛芬之前以及给药后30、60、90、120、180和240分钟记录体温。评估年龄、性别、体重、体表面积、疾病实体、先前的退热治疗以及体格测量与体温变化之间的关联。
共研究了384名儿童。基线体温在38摄氏度至42摄氏度之间（平均：39.1±60.6）。大多数患者（77.8%）发热超过6小时，59.5%接受过退热治疗。93.5%的儿童体温降至37.5摄氏度或更低。80.2%的儿童在治疗后12小时达到该体温。95%的儿童体温至少下降1摄氏度。年龄较大（比值比1.67；95%置信区间：1.03至2.7）、体表面积较小（比值比0.004；95%置信区间0.00至0.89）和基线体温较低（比值比0.008；95%置信区间0.00至0.14）与较小的退热反应（体温下降低于1摄氏度）相关。
布洛芬对儿童发热治疗有效。其有效性与年龄、发热程度和体表面积有关。
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