Häusser M, Major G, Stuart G J
Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK.
Science. 2001 Jan 5;291(5501):138-41. doi: 10.1126/science.291.5501.138.
Neurons encode information and communicate via action potentials, which are generated following the summation of synaptic events. It is commonly assumed that action potentials reset the membrane potential completely, allowing another round of synaptic integration to begin. We show here that the conductances underlying the action potential act instead as a variable reset of synaptic integration. The strength of this reset is cell type-specific and depends on the kinetics, location, and timing of the synaptic input. As a consequence, distal synapses, as well as inputs mediated by N-methyl-d-aspartate receptor activation, can contribute disproportionately to synaptic integration during action potential firing.
神经元通过动作电位来编码信息并进行通讯，动作电位是在突触事件总和之后产生的。通常认为动作电位会完全重置膜电位，从而开启另一轮突触整合。我们在此表明，动作电位背后的电导实际上起到了对突触整合的可变重置作用。这种重置的强度具有细胞类型特异性，并且取决于突触输入的动力学、位置和时间。因此，远端突触以及由N-甲基-D-天冬氨酸受体激活介导的输入，在动作电位发放期间对突触整合的贡献可能不成比例。
