Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Neuroscience Graduate Program, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Eur J Neurosci. 2022 Nov;56(9):5564-5586. doi: 10.1111/ejn.15636. Epub 2022 Mar 14.
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by behavioural changes that include memory loss and cognitive decline and is associated with the appearance of amyloid-β plaques and neurofibrillary tangles throughout the brain. Although aspects of the disease percolate across multiple levels of neuronal organization, from the cellular to the behavioural, it is increasingly clear that circuits are a critical junction between the cellular pathology and the behavioural phenotypes that bookend these levels of analyses. In this review, we discuss critical aspects of neural circuit research, beginning with synapses and progressing to network activity and how they influence our understanding of disease processed in AD.
阿尔茨海默病（AD）是一种神经退行性疾病，其特征是行为改变，包括记忆丧失和认知能力下降，并且与大脑中出现淀粉样β斑块和神经原纤维缠结有关。尽管该疾病的各个方面都涉及到神经元组织的多个层次，从细胞到行为，但越来越明显的是，回路是细胞病理学与行为表型之间的关键连接点，这些表型是这些分析水平的两端。在这篇综述中，我们讨论了神经回路研究的关键方面，从突触开始，一直到网络活动，以及它们如何影响我们对 AD 中疾病过程的理解。
