艾滋病相关系统性非霍奇金淋巴瘤
AIDS related systemic non-Hodgkin's lymphoma.
作者信息
Powles T, Matthews G, Bower M
机构信息
Department Oncology, Chelsea and Westminster Hospital, London SW10 9NH, UK.
出版信息
Sex Transm Infect. 2000 Oct;76(5):335-41. doi: 10.1136/sti.76.5.335.
OBJECTIVE
To review the current literature on HIV associated non-Hodgkin's lymphoma.
METHODS
A comprehensive Medline/Pubmed search of articles pertaining to HIV associated non-Hodgkin's lymphoma as well as personal experience from the treatment of over 200 patients at the Chelsea and Westminster Hospital, one of the largest centres for the management of HIV disease in Europe.
CONCLUSION
High grade B cell non-Hogdkin's lymphoma is the second commonest tumour affecting people with HIV. The incidence of this tumour is not declining following the introduction of highly active antiretroviral therapy. Chemotherapy has been employed with modest success in this group of patients; however, the prognosis remains worse than for immunocompetent patients. Advances in molecular genetics and virology have led to a greater understanding of the biology of these tumours. However, these advances have yet to be translated into improvements in the clinical management of patients with AIDS associated non-Hodgkin's lymphoma.
目的
回顾目前关于人类免疫缺陷病毒（HIV）相关非霍奇金淋巴瘤的文献。
方法
通过全面检索医学文献数据库（Medline/Pubmed）中与HIV相关非霍奇金淋巴瘤相关的文章，并结合在欧洲最大的HIV疾病管理中心之一切尔西和威斯敏斯特医院对200多名患者的治疗经验。
结论
高级别B细胞非霍奇金淋巴瘤是影响HIV感染者的第二常见肿瘤。在引入高效抗逆转录病毒治疗后，这种肿瘤的发病率并未下降。化疗在这组患者中取得了一定成效；然而，其预后仍比免疫功能正常的患者更差。分子遗传学和病毒学的进展使人们对这些肿瘤的生物学特性有了更深入的了解。然而，这些进展尚未转化为艾滋病相关非霍奇金淋巴瘤患者临床管理的改善。
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