Meloni G, Proia A, Guerrisi V, Cordone I, De Cuia R, Fenu S, Mauro F R, Pescarmona E, Reato G, Mandelli F
Dipartimento di Biotecnologie Cellulari ed Ematologia, University La Sapienza, Roma, Italy.
Ann Oncol. 2000 Nov;11(11):1493-5. doi: 10.1023/a:1026505632679.
An increased incidence of different malignancies associated to chronic lymphocytic leukemia (CLL) has been reported. The association of CLL and acute leukemia is a rare event described in < 1% of CLL, the type of acute leukemia being either from the lymphoid or more often from the myeloid lineage. The coexistence of acute myeloid leukemia (AML) and CLL in the same patient has been occasionally reported. Most of these cases have been associated with the administration of chemotherapy or radiotherapy for CLL, suggesting that the former may be a secondary leukemia. On the other hand, CLL could precede, but could also be diagnosed at the same, or delayed time as AML, suggesting the presence of other leukemogenic factors. We describe the exceptional development of AML and lung cancer in a patient with previously diagnosed CLL in minimal residual disease status after fludarabine treatment followed by autologous peripheral blood stem-cell transplantation.
据报道，与慢性淋巴细胞白血病（CLL）相关的不同恶性肿瘤的发病率有所增加。CLL与急性白血病的关联是一种罕见事件，在<1%的CLL中有所描述，急性白血病的类型要么是淋巴系的，要么更常见的是髓系的。同一患者中急性髓系白血病（AML）和CLL并存的情况偶尔有报道。这些病例大多与CLL的化疗或放疗有关，提示前者可能是继发性白血病。另一方面，CLL可能先于AML出现，但也可能与AML同时诊断或在其之后诊断，这表明存在其他致白血病因素。我们描述了一名先前诊断为CLL的患者在氟达拉滨治疗后处于微小残留病状态并接受自体外周血干细胞移植后，发生AML和肺癌的罕见情况。
