Tuinstra T, Verheij M, Willemen A, Iking J, Heeren D J, Cools A R
Department of Psychoneuropharmacology, Nijmegen Institute for Neurosciences, University of Nijmegen, The Netherlands.
Behav Neurosci. 2000 Dec;114(6):1088-95. doi: 10.1037//0735-7044.114.6.1088.
Rats selected on the basis of their apomorphine susceptibility or on the basis of their response to novelty were used to investigate the role of mesolimbic adrenoceptors in the retrieval of spatial information in the water maze task. Apomorphine-susceptible rats and high responders to novelty (HR) showed a relatively bad retrieval during the 1st trial of the 2nd day compared with apomorphine-unsusceptible rats and low responders to novelty (LR). Intra-accumbens injections of different doses of the beta-agonist isoproterenol, given just before that trial, disrupted the retrieval in LR rats but not in HR rats. The beta-antagonist propranolol, which itself did not have any direct effect, inhibited the effect of isoproterenol in LR rats. The effect of isoproterenol in LR rats was not modified by alpha-agents. It is concluded that the beta-adrenergic, but not alpha-adrenergic, activity in the nucleus accumbens directs the individual-specific ability to retrieve spatial information under stressful conditions.
基于阿扑吗啡敏感性或对新奇事物反应而挑选出的大鼠，被用于研究中脑边缘肾上腺素能受体在水迷宫任务中空间信息检索方面的作用。与阿扑吗啡不敏感大鼠和对新奇事物低反应者（LR）相比，阿扑吗啡敏感大鼠和对新奇事物高反应者（HR）在第二天的首次试验中表现出相对较差的检索能力。在该试验前即刻向伏隔核内注射不同剂量的β-激动剂异丙肾上腺素，会扰乱LR大鼠的检索能力，但对HR大鼠无此影响。β-拮抗剂普萘洛尔本身无直接作用，但能抑制异丙肾上腺素对LR大鼠的影响。α-药物不会改变异丙肾上腺素对LR大鼠的作用。得出的结论是，伏隔核中的β-肾上腺素能而非α-肾上腺素能活性，在应激条件下指导个体检索空间信息的特定能力。
