Scheib S G, Gianolini S, Haller D, Wellis G N, Siegfried J
Klinik Im Park, Gamma Knife Center Zurich, Switzerland.
J Neurosurg. 2000 Dec;93 Suppl 3:203-7. doi: 10.3171/jns.2000.93.supplement.
In clinical follow-up studies after radiosurgery, imaging modalities such as computerized tomography (CT) and magnetic resonance (MR) imaging are used. Accurate determination of the residual lesion volume is necessary for realistic assessment of the effects of treatment. Usually, the diameters rather than the volume of the lesion are measured. To determine the lesion volume without using stereotactically defined images, the software program VOLUMESERIES has been developed. VOLUMESERIES is a personal computer-based image analysis tool. Acquired DICOM CT scans and MR image series can be visualized. The region of interest is contoured with the help of the mouse, and then the system calculates the volume of the contoured region and the total volume is given in cubic centimeters. The defined volume is also displayed in reconstructed sagittal and coronal slices. In addition, distance measurements can be performed to measure tumor extent. The accuracy of VOLUMESERIES was checked against stereotactically defined images in the Leksell GammaPlan treatment planning program. A discrepancy in target volumes of approximately 8% was observed between the two methods. This discrepancy is of lesser interest because the method is used to determine the course of the target volume over time, rather than the absolute volume. Moreover, it could be shown that the method was more sensitive than the tumor diameter measurements currently in use. VOLUMESERIES appears to be a valuable tool for assessing residual lesion volume on follow-up images after gamma knife radiosurgery while avoiding the need for stereotactic definition.
在放射外科手术后的临床随访研究中，会使用计算机断层扫描（CT）和磁共振成像（MR）等成像方式。准确测定残留病灶体积对于实际评估治疗效果是必要的。通常，测量的是病灶的直径而非体积。为了在不使用立体定向定义图像的情况下测定病灶体积，已开发了软件程序VOLUMESERIES。VOLUMESERIES是一种基于个人计算机的图像分析工具。可以可视化获取的DICOM CT扫描图像和MR图像序列。借助鼠标勾勒出感兴趣区域，然后系统计算勾勒区域的体积，并以立方厘米给出总体积。定义的体积也会显示在重建的矢状面和冠状面切片中。此外，可以进行距离测量以测量肿瘤范围。在Leksell GammaPlan治疗计划程序中，对照立体定向定义图像检查了VOLUMESERIES的准确性。两种方法之间观察到目标体积存在约8%的差异。由于该方法用于确定目标体积随时间的变化过程，而非绝对体积，所以这种差异的影响较小。此外，可以证明该方法比目前使用的肿瘤直径测量方法更敏感。VOLUMESERIES似乎是一种有价值的工具，可用于评估伽玛刀放射外科手术后随访图像上的残留病灶体积，同时无需立体定向定义。
