Hsu C Y, Brooker G, Peach M J, Westfall T C
Science. 1975 Mar 21;187(4181):1086-7. doi: 10.1126/science.1114337.
Tolbutamide and other sulfonylureas inhibited spontaneous and nicotine-induced release of catecholamines from the perfused cat adrenal gland and nicotine-induced release of [3-H]norepinephrine from isolated guinea pig hearts. Of the sulfonylureas tested, the order to potency of this inhibitory effect paralled the hypoglycemic action. These results raise the possibility that the inhibition of the sympathoadrenal system may contribute in part to the hypoglycemic action of sulfonylureas.
甲苯磺丁脲和其他磺酰脲类药物可抑制灌流猫肾上腺中儿茶酚胺的自发释放和尼古丁诱导的释放，以及离体豚鼠心脏中尼古丁诱导的[3-H]去甲肾上腺素的释放。在所测试的磺酰脲类药物中，这种抑制作用的效力顺序与降血糖作用平行。这些结果提示，抑制交感肾上腺系统可能在一定程度上有助于磺酰脲类药物的降血糖作用。
