[The effect of local specific bronchial immunotherapy (LIT) on specific and non-specific bronchial hyperreactivity in patients with bronchial asthma sensitive to housedust mites].

The aim of the study was to evaluate the effect of LIT with mite allergens given by dry powder inhalation on bronchial hyperreactivity after histamine and allergen inhalation in patients suffering from atopic mite asthma. The study was conducted in a group of 17 asthmatics (9 patients Hypoinhal Dermatophagoides, 8 patients placebo). A decrease in specific (early asthmatic reaction during specific bronchial provocation test) and non-specific bronchial hyperreactivity has been revealed in the group treated with Hypoinhal Dermatophagoides. No changes were observed in placebo group. A slight improvement in LAR (late asthmatic reaction during specific bronchial provocation test) was observed, but the results were not statistically significant.