Sequence analysis of a new HLA-DR11 allele in a Caucasian Italian family: DRB1*11272.

This communication describes a new DRB111 allele identified in a familial group of Caucasian individuals from central Italy. The new sequence has been officially named DRB111272 by the World Health Organization (WHO) Nomenclature Committee (February 2000). It encodes an HLA antigen serologically recognized as DR11. The sequence variation of this new allele was localized to codon 77 of exon 2. It differs at position 230 from DRB111011 allele (A replacing C), and at position 231 from DRB11127 (C replacing T). At the amino acid level, the DRB111272 mutation is silent with respect to the DRB1127 phenotype, coding for a synonymous asparagine.