Zanoboni A, Zanoboni-Muciaccia W, Zanussi C
Acta Endocrinol (Copenh). 1979 Jun;91(2):257-63. doi: 10.1530/acta.0.0910257.
Sulpiride, a specific dopaminergic blocker, was administered im to 6 normal male volunteers (100 mg) alone or in association with L-DOPA (500 mg per os, 90 min before sulpiride) or with TRH (400 micrograms iv in bolus, 30 min after sulpiride) and blood samples were obtained for TSH radioimmunoassay at various intervals before and after the treatments. Sulpiride alone produced a slight increase of plasma TSH levels which was inhibited by L-DOPA pre-treatment. The previous administration of sulpiride resulted in a marked increase of the TSH response to TRH. It is suggested that dopamine and TRH may interact to modulate pituitary secretion of both TSH and prolactin, though the hypophyseal thyrotrophs and lactotrophs show a different sensitivity to the common stimulatory and inhibitory substances.
舒必利是一种特异性多巴胺能阻滞剂，单独给6名正常男性志愿者肌肉注射（100毫克），或与左旋多巴联合使用（口服500毫克，在舒必利前90分钟给药），或与促甲状腺激素释放激素联合使用（静脉推注400微克，在舒必利后30分钟给药），并在治疗前后的不同时间间隔采集血样进行促甲状腺激素放射免疫测定。单独使用舒必利会使血浆促甲状腺激素水平略有升高，而左旋多巴预处理可抑制这种升高。预先给予舒必利会导致促甲状腺激素对促甲状腺激素释放激素的反应显著增加。这表明多巴胺和促甲状腺激素释放激素可能相互作用，调节垂体促甲状腺激素和催乳素的分泌，尽管垂体促甲状腺细胞和催乳细胞对共同的刺激和抑制物质表现出不同的敏感性。
