在正常受试者中，同时给予促甲状腺激素释放激素（TRH）和舒必利会引起催乳素（PRL）反应的相加作用，但无协同作用。

Simultaneous administration of TRH and sulpiride caused additive but not synergistic PRL responses in normal subjects.

作者信息

Hanew K, Utsumi A, Sugawara A, Shimizu Y, Yoshinaga K

机构信息

Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.

出版信息

Endocrinol Jpn. 1992 Oct;39(5):465-8. doi: 10.1507/endocrj1954.39.465.

DOI:10.1507/endocrj1954.39.465

PMID:1478187

Abstract

In order to study the mode of action of TRH and sulpiride in man, we administered TRH (500 micrograms, iv) and sulpiride (DA D2 receptor antagonist, 100 mg, im) simultaneously to 6 normal females (20-21 yr). Normal females showed significantly greater PRL increments and AUC in response to the combined administration compared to a single administration of each agent (P < 0.05-0.01), while the increment and AUC in response to the combination did not exceed the sum of those responses to a single administration. In contrast, the combined administration of TRH and sulpiride did not elicit an enhanced response of plasma TSH. These results indicate that the sites of action of TRH and sulpiride might be different from each other, and these agents work additively with no interaction in human lactotrophs.

摘要

为研究促甲状腺激素释放激素（TRH）和舒必利在人体中的作用方式，我们对6名正常女性（20 - 21岁）同时静脉注射TRH（500微克）和肌肉注射舒必利（多巴胺D2受体拮抗剂，100毫克）。与单独给予每种药物相比，正常女性在联合给药后催乳素（PRL）的升高幅度和曲线下面积（AUC）显著更大（P < 0.05 - 0.01），而联合给药后的升高幅度和AUC并未超过单独给药时反应的总和。相比之下，TRH和舒必利联合给药并未引起血浆促甲状腺激素（TSH）反应增强。这些结果表明，TRH和舒必利的作用位点可能彼此不同，且这些药物在人类泌乳细胞中起相加作用，不存在相互作用。