Friedman M H, Henderson J M, Aukerman J A, Clingan P A
Biomedical Engineering Center, Ohio State University, Columbus, OH 43210, USA.
Biorheology. 2000;37(4):265-77.
Experiments were carried out in swine to test the hypothesis that changes in the fluid dynamic environment of the arterial wall, with time constants of several minutes to perhaps a few hours, prompt adaptive responses that transiently increase endothelial permeability. After parenteral Evans Blue Dye (EBD) administration, the hemodynamics of the external iliac arteries of the experimental animals were altered using a reversible arteriovenous femoral shunt. For 3 h, the shunt was opened and closed with a period (tau) between 1-180 min. Subsequently, the animal was euthanized and the iliac vessels were photographed en face to obtain the distribution of EBD-bound albumin uptake by the tissue during its exposure to the dye. Albumin uptake increases with tau in a fashion that can be explained by an a priori model of the adaptive permeability response, with a time constant of about an hour.
在猪身上进行了实验，以检验以下假设：动脉壁流体动力学环境的变化，其时间常数从几分钟到可能几小时不等，会引发适应性反应，使内皮通透性短暂增加。经肠胃外注射伊文思蓝染料（EBD）后，使用可逆的股动静脉分流术改变实验动物髂外动脉的血流动力学。在3小时内，分流器以1至180分钟的周期（τ）打开和关闭。随后，对动物实施安乐死，并对髂血管进行正面拍照，以获取组织在接触染料期间EBD结合白蛋白摄取的分布情况。白蛋白摄取量随τ增加，其方式可用适应性通透性反应的先验模型解释，时间常数约为一小时。
