Amadori S, Petti M C, Mastrovincenzo C, Testa M G
Acta Haematol. 1979;61(5):237-42. doi: 10.1159/000207666.
Cell kinetic changes induced in the marrow blasts by treatment with a triple cytotoxic regimen including daunorubicin, cytosine arabinoside and 6-thioguanine (DAT) were investigated in 6 previously untreated acute nonlymphocytic leukemia patients. A decrease in the labeling and mitotic indices was consistently observed 24 h after administration of daunorubicin, suggesting a G2 block and a preferential lytic effect on the S-phase cells operated by the drug. Conversely, cytosine arabinoside and 6-thioguanine in combination induced a series of kinetic perturbations variable from case to case; however, three principal patterns of kinetic response were recogized and discussed in detail. Useful information for the planning of a more rational antileukemic therapy can be drawn from a systematic study of the kinetic effects induced by drug combinations.
在6例未经治疗的急性非淋巴细胞白血病患者中，研究了包括柔红霉素、阿糖胞苷和6-硫鸟嘌呤（DAT）的三联细胞毒性方案治疗对骨髓母细胞诱导的细胞动力学变化。在给予柔红霉素24小时后，始终观察到标记指数和有丝分裂指数下降，提示存在G2期阻滞以及该药物对S期细胞的优先裂解作用。相反，阿糖胞苷和6-硫鸟嘌呤联合使用会引起一系列因病例而异的动力学扰动；然而，识别并详细讨论了三种主要的动力学反应模式。通过对药物组合诱导的动力学效应进行系统研究，可以为规划更合理的抗白血病治疗提供有用信息。
