Timmermans J P, Hens J, Adriaensen D
Laboratory of Cell Biology and Histology, University of Antwerp, Antwerp, Belgium.
Anat Rec. 2001 Jan 1;262(1):71-8. doi: 10.1002/1097-0185(20010101)262:1<71::AID-AR1012>3.0.CO;2-A.
The architecture of the enteric nerve networks in the gastrointestinal tract appears to be more complex in large mammals, including humans, than in small laboratory animals. At least two distinct ganglionic nerve plexuses could be identified in the submucous layer in the digestive tract of large mammals. While functionally and morphologically similar neuron populations are found in the intestinal wall of both small and large mammals, significant differences in their topographical organization and neurochemical features may be present. This short review clearly illustrates that the close and exclusive association, which has been assumed so far between the efferent pathways of the submucous plexus and regulation of intestinal secretion/absorption on the one hand and between the myenteric plexus and regulation of intestinal motility on the other hand, cannot be interpreted that strictly. An attempt has been made to give a briefoverview of the current status of the identification of distinct functional enteric neuronal classes in the gastrointestinal tract of large mammals using the pig and human intestine as references, and to compare these data with the more extensive information gathered from the guinea-pig intestine.
包括人类在内的大型哺乳动物胃肠道内的肠神经网络结构，似乎比小型实验动物更为复杂。在大型哺乳动物消化道的黏膜下层，至少可以识别出两个不同的神经节神经丛。虽然在小型和大型哺乳动物的肠壁中都发现了功能和形态相似的神经元群体，但它们在拓扑结构和神经化学特征上可能存在显著差异。这篇简短的综述清楚地表明，迄今为止所假定的黏膜下神经丛传出通路与肠分泌/吸收调节之间，以及肌间神经丛与肠动力调节之间紧密且唯一的关联，不能被如此严格地解读。本文尝试以猪和人类肠道为参考，简要概述大型哺乳动物胃肠道中不同功能性肠神经元类别的识别现状，并将这些数据与从豚鼠肠道收集到的更广泛信息进行比较。
