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[手部骨肉瘤治疗后医源性肿瘤转移至骨盆。病例报告]

[Iatrogenic tumor metastasis to the pelvis after treatment for hand osteosarcoma. A case report].

作者信息

Ebelin M, Missenard G, Nordin J Y

机构信息

Service de chirurgie orthopédique et réparatrice, centre hospitalier universitaire de Bicêtre, 78, rue du Général Leclerc, 94275 Le Kremlin Bicêtre.

出版信息

Chir Main. 2000 Nov;19(5):272-5. doi: 10.1016/s1297-3203(00)73491-3.

DOI:10.1016/s1297-3203(00)73491-3
PMID:11147201
Abstract

In this study, the case has been examined of a 49-year old male who initially presented with a pathological fracture of the second metacarpal. This was first treated by curettage, iliac bone graft and internal fixation, without any complementary investigation being carried out, i.e., no preliminary biopsy and histological diagnosis were made. The results of this inadequate approach were poor: neither satisfactory fixation of the fracture nor control of the primary lesion were obtained. Moreover, the definitive diagnosis was only made four months later, when biopsy findings confirmed the presence of an osteosarcoma. After neoadjuvant chemotherapy, an en-bloc resection of the second metatarsal and the trapezoid bone was carried out. At ten months post-surgery, one and a half years after the original fracture, the hand was found to be disease-free and functioning satisfactory. However, nearly a year later the discovery of a large tumor mass at the site where the iliac bone graft was originally taken necessitated resection of the hemi-pelvis, with chemotherapy prior to resection and radiotherapy following surgery. Unfortunately, this salvage procedure did not limit the spread of the disease, and subsequent pulmonary and vertebral metastases were found, leading to the death of the patient three years after the initial fracture. This particular case underlines the fact that the basic rules for the management of malignant tumors should be taken into consideration from the onset, so that a catastrophic prognosis such as that described can be avoided.

摘要

在本研究中,对一名49岁男性病例进行了检查,该患者最初表现为第二掌骨病理性骨折。最初采用刮除术、髂骨移植和内固定进行治疗,未进行任何补充检查,即未进行初步活检和组织学诊断。这种不充分治疗方法的结果很差:既未获得骨折的满意固定,也未控制原发性病变。此外,直到四个月后活检结果证实存在骨肉瘤时才做出明确诊断。新辅助化疗后,对第二跖骨和大多角骨进行了整块切除。术后十个月,即原始骨折后一年半,发现手部无疾病且功能良好。然而,近一年后,在最初取髂骨移植的部位发现一个大肿瘤块,需要切除半骨盆,术前进行化疗,术后进行放疗。不幸的是,这种挽救性手术并未限制疾病的扩散,随后发现了肺部和椎体转移,导致患者在原始骨折三年后死亡。这个特殊病例强调了一个事实,即从一开始就应考虑恶性肿瘤管理的基本规则,以避免出现所述的灾难性预后。

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Isolated Osseous Excision in the Adult Carpus: A Narrative Review.成人腕骨孤立性骨切除术:一项叙述性综述
J Hand Microsurg. 2024 May 14;16(2):100041. doi: 10.1055/s-0043-1769748. eCollection 2024 Jun.
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Iatrogenic giant cell tumor at bone graft harvesting site.骨移植取材部位的医源性巨细胞瘤
Indian J Orthop. 2013 Jan;47(1):107-10. doi: 10.4103/0019-5413.106936.