George M S, Sackeim H A, Marangell L B, Husain M M, Nahas Z, Lisanby S H, Ballenger J C, Rush A J
Department of Psychiatry, Medical University of South Carolina, USA.
Psychiatr Clin North Am. 2000 Dec;23(4):757-83. doi: 10.1016/s0193-953x(05)70196-9.
VNS builds on a long history of investigating the relationship of autonomic signals to limbic and cortical function and is one of the newest methods to physically alter brain function. VNS is a clinically useful anticonvulsant therapy in treatment resistant patients with epilepsy, and pilot data suggest that it has potential as an antidepressant therapy. The known anatomic projections of the vagus nerve suggest that VNS also might have other neuropsychiatric applications. Additional research is needed to clarify the mechanisms of action of VNS and the potential clinical utility of this intriguing new somatic portal into the CNS.
迷走神经刺激（VNS）建立在对自主神经信号与边缘系统及皮质功能关系进行研究的悠久历史之上，是最新的物理改变脑功能的方法之一。VNS是一种对难治性癫痫患者临床有用的抗惊厥疗法，初步数据表明它有作为抗抑郁疗法的潜力。迷走神经已知的解剖投射表明VNS可能还有其他神经精神方面的应用。需要进一步研究以阐明VNS的作用机制以及这种引人入胜的新的进入中枢神经系统的躯体途径的潜在临床效用。
