Kolbitsch C, Lorenz H I, Hörmann C, Schocke M, Felber S, Zschiegner F, Pfeiffer P K, Benzer A
Department of Anaesthesia and Intensive Care Medicine, University of Innsbruck, Austria.
J Neurosurg Anesthesiol. 2000 Oct;12(4):319-23. doi: 10.1097/00008506-200010000-00004.
The use of sevoflurane is favored for its rapid onset and offset of anesthesia as well as good intraoperative titratability of the anesthetic. With regard to neuroanesthesia, the reported effects of sevoflurane on cerebral hemodynamics and cerebrospinal fluid dynamics are inconsistent. We used phase-contrast magnetic resonance imaging measurement of systolic cerebrospinal fluid peak velocity (CSFVPeak) to evaluate the effect of sevoflurane on cerebral compliance in healthy individuals. During administration of 0.4 MAC sevoflurane, systolic CSFVPeak in the aqueduct of Sylvius remained unchanged, thereby indicating unaffected cerebral compliance: (CSFVPeak baseline: -3.1 +/- 1.0 cm/s vs. sevoflurane: -3.0 +/- 1.2 cm/s). We conclude that low-dose administration of sevoflurane does not influence cerebral compliance in healthy individuals, but the influence of coexisting intracranial pathology or comedications on cerebral compliance requires further clinical investigation.
七氟醚的使用因其麻醉起效和消退迅速以及术中麻醉良好的可滴定性而受到青睐。关于神经麻醉，七氟醚对脑血流动力学和脑脊液动力学的报道影响并不一致。我们使用相位对比磁共振成像测量收缩期脑脊液峰值流速（CSFVPeak）来评估七氟醚对健康个体脑顺应性的影响。在给予0.4MAC七氟醚期间，中脑导水管的收缩期CSFVPeak保持不变，从而表明脑顺应性未受影响：（CSFVPeak基线：-3.1±1.0cm/s vs七氟醚：-3.0±1.2cm/s）。我们得出结论，低剂量七氟醚给药不影响健康个体的脑顺应性，但并存的颅内病变或合并用药对脑顺应性的影响需要进一步的临床研究。
