Petty T L
University of Colorado Health Sciences Center, Denver 80218, USA.
Cancer. 2000 Dec 1;89(11 Suppl):2461-4. doi: 10.1002/1097-0142(20001201)89:11+<2461::aid-cncr23>3.3.co;2-c.
Sputum cytology was considered to be ineffective in previous National Cancer Institute trials for early lung carcinoma detection. However, sputum cytology was effective in identifying roentgenographically occult lung carcinoma in a community lung carcinoma identification program, where lung carcinoma was suspected on the basis of symptoms, smoking, or airflow obstruction.
The community project and the results of a newer lung carcinoma identification program were reviewed.
Actuarial survival curves from a previously published study where 46 of 51 roentgenographically occult carcinomas could be treated by surgery (n = 27) or curative radiation therapy (n = 19) is presented. Overall survival, taking deaths from all causes at five years, was 54.4%. The serial study of high risk patients with airflow obstruction and more than 30 pack-years of smoking revealed a 1.8% yield of lung carcinoma. This is a higher yield than in mammography (0.3%-0.5%).
Sputum cytology can be useful in identifying lung carcinoma in its early and occult stages, particularly in patients at high risk for this disease.
在先前美国国立癌症研究所开展的早期肺癌检测试验中，痰细胞学检查被认为效果不佳。然而，在一项社区肺癌识别项目中，痰细胞学检查对于识别影像学隐匿性肺癌是有效的，该项目中根据症状、吸烟或气流阻塞怀疑患有肺癌。
回顾了该社区项目以及一项更新的肺癌识别项目的结果。
展示了一项先前发表研究中的精算生存曲线，该研究中51例影像学隐匿性癌中的46例可通过手术（n = 27）或根治性放射治疗（n = 19）进行治疗。以五年内所有原因导致的死亡计算，总体生存率为54.4%。对气流阻塞且吸烟超过30包年的高危患者进行的系列研究显示肺癌检出率为1.8%。这一检出率高于乳房X线摄影检查（0.3% - 0.5%）。
痰细胞学检查有助于在肺癌的早期和隐匿阶段进行识别，尤其是对于该疾病的高危患者。
