Nicoletti A, Lo Bartolo M L, Lo Fermo S, Cocuzza V, Panetta M R, Marletta C, Ciancio M R, Cataldi M L, Patti F, Reggio A
Institute of Neurological Science, University of Catania, Italy.
Neurology. 2001 Jan 9;56(1):62-6. doi: 10.1212/wnl.56.1.62.
An epidemiologic survey was conducted to determine the prevalence and incidence of MS in the city of Catania, Sicily, Italy. Prevalence rate was calculated as point prevalence at January 1,1995, and incidence during 1974 to 1995.
The authors studied the frequency of MS in the community of Catania in a population of 333,075 inhabitants according to the 1991 census. The primary sources for the case ascertainment were the neurologic and motor rehabilitation departments, the MS Center, the Italian MS Association, private neurologists, and family doctors. All patients who satisfied the Poser criteria for clinically definite MS, laboratory-supported definite MS, clinically probable MS, and laboratory-supported probable MS were considered prevalent and incident cases.
One hundred ninety-five patients with MS who had had the onset of disease on prevalence day in a population of 333,075 inhabitants were detected. The prevalence rate was 58.5 per 100,000 (95% CI 50.7 to 67.5). Prevalence was higher in women (62.0/100,000) than in men (54.8/100,000). The age-specific prevalence showed a peak in the group aged 35 to 44 (145.1/100,000). From 1975 to 1994, 170 subjects with MS had the clinical onset of the disease. The mean annual incidence was 2.3 per 100,000 (95% CI 2.0 to 2.6). Age-specific incidence showed a peak in the group aged 25 to 34 (6.32/100,000). Incidence for 5-year intervals increased from 1.3 during 1975 to 1979 to 3.9 during 1990 to 1994.
These prevalence and incidence rates are close to those reported in other similar surveys carried out in Italy and southern Europe.
开展一项流行病学调查，以确定意大利西西里岛卡塔尼亚市多发性硬化症（MS）的患病率和发病率。患病率计算为1995年1月1日的时点患病率，发病率计算为1974年至1995年期间的发病率。
作者根据1991年人口普查，在卡塔尼亚社区333,075名居民中研究MS的发病频率。病例确诊的主要来源是神经科和运动康复科、MS中心、意大利MS协会、私人神经科医生和家庭医生。所有符合波泽尔标准的临床确诊MS、实验室支持确诊MS、临床可能MS和实验室支持可能MS的患者均被视为现患病例和新发病例。
在333,075名居民中，检测到195例在患病率调查日发病的MS患者。患病率为每10万人58.5例（95%可信区间50.7至67.5）。女性患病率（每10万人62.0例）高于男性（每10万人54.8例）。年龄别患病率在35至44岁组达到峰值（每10万人145.1例）。1975年至1994年，170名MS患者出现临床发病。年平均发病率为每10万人2.3例（95%可信区间2.0至2.6）。年龄别发病率在25至34岁组达到峰值（每10万人6.32例）。5年间隔的发病率从1975年至1979年的1.3上升至1990年至1994年的3.9。
这些患病率和发病率与意大利和南欧其他类似调查报道的结果相近。
