组织细胞吞噬性脂膜炎中吞噬活性的监测

Monitoring of phagocytic activity in histiocytic cytophagic panniculitis.

作者信息

Zollner T M, Podda M, Ochsendorf F R, Wolter M, Kaufmann R, Boehncke W H

机构信息

Department of Dermatology, University of Frankfurt Medical School, Frankfurt/Main, Germany.

出版信息

J Am Acad Dermatol. 2001 Jan;44(1):120-3. doi: 10.1067/mjd.2001.107775.

DOI:10.1067/mjd.2001.107775

PMID:11148488

Abstract

Histiocytic cytophagic panniculitis presents with subcutaneous panniculitis. Histologically, it is characterized by phagocytosis of blood cells in the subcutaneous tissue and bone marrow. One patient with histiocytic cytophagic panniculitis is described in whom hemophagocytosis macrophages and histiocytes was observed histologically and was confirmed in vitro measuring phagocytosis by peripheral blood monocytes by means of chemiluminescence. In vitro measurements of phagocytosis corresponded well with the clinical course. Chemiluminescence for measuring phagocytosis in vitro may be suitable for analyzing disease activity and for testing therapeutic compounds in vitro.

摘要

组织细胞性噬血细胞性脂膜炎表现为皮下脂膜炎。组织学上，其特征是皮下组织和骨髓中血细胞被吞噬。本文描述了1例组织细胞性噬血细胞性脂膜炎患者，组织学观察到噬血细胞的巨噬细胞和组织细胞，并通过化学发光法体外测量外周血单核细胞的吞噬作用得以证实。体外吞噬作用测量结果与临床病程高度相符。体外测量吞噬作用的化学发光法可能适用于分析疾病活动度以及体外测试治疗性化合物。