Abundant human beta-defensin-1 expression in milk and mammary gland epithelium.
作者信息
Jia H P, Starner T, Ackermann M, Kirby P, Tack B F, McCray P B
机构信息
Department of Pediatrics, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA.
出版信息
J Pediatr. 2001 Jan;138(1):109-12. doi: 10.1067/mpd.2001.109375.
PMID:11148522
Abstract
Human beta-defensin-1 (HBD-1) was detected in breast milk in concentrations of approximately 1 to 10 microg/mL. Breast tissue during lactation showed HBD-1 expression in mammary gland epithelia and within luminal secretions. The peptide demonstrated antimicrobial activity against Escherichia coli. HBD-1 may augment neonatal host defenses through antimicrobial effects or prime the adaptive immune system at mucosal surfaces.
摘要
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