The relationship between dysfunctional voiding and congenital vesicoureteral reflux.

Voiding dysfunction may play an etiological role in congenital vesicoureteral reflux in otherwise normal children. There is increasing evidence to suggest that in some infants and older children, vesicoureteral reflux is associated with congenital structural deficiency of the trigonal ureterovesical junction valve mechanism as well as aberrant lower urinary tract function. In the youngest infants this abnormal function can be present at birth, whereas in older children it may be acquired and learned during the toilet training years, if it is not already present. Voiding dysfunction may spontaneously improve or require additional therapy. Increased rates of breakthrough infection, renal scarring and surgical failure have been associated with undiagnosed and untreated lower urinary tract dysfunction, emphasizing the importance of its recognition. Controversy remains regarding the role of invasive urodynamics and anticholinergic medication, and further large-scale prospective studies are necessary before either modality becomes routine when assessing and treating these children.