Monticelli A, Lewi D, Salomon H, Pampuro S, Libonatti O, Jauregui Rueda H, Hodara V
FAIVIH/S (Fundación de Asistencia e Información en VIH/SIDA), Buenos Aires, Argentina.
Rev Argent Microbiol. 2000 Oct-Dec;32(4):206-8.
The aim of the study was to assess regression of Kaposi's sarcoma (KS) in AIDS patients in Argentina. Eighteen male AIDS patients with human immunodeficiency virus (HIV)-associated Kaposi's sarcoma at different clinical stages received KS specific treatment and/or anti-retroviral therapy. Triple anti-retroviral therapy was given to most of the patients with the exception of four who received zidovudine (ZDV) in combination with another nucleoside analogue but no protease inhibitors. Plasma viral load and CD4+ T lymphocyte number were measured in two blood samples (before and after treatment). Complete remission was found in all patients (five) at KS stage I, three out of eight patients at stage II but in none at stages III and IV. Two out of three patients at KS stage IV did not respond to treatments at all. Three patients at KS stages I and II showed complete remission of sarcoma with only anti-retroviral therapy suggesting that anti-retroviral therapy and non-KS specific chemotherapy can successfully control KS.
该研究的目的是评估阿根廷艾滋病患者中卡波西肉瘤（KS）的消退情况。18名处于不同临床阶段、患有与人类免疫缺陷病毒（HIV）相关的卡波西肉瘤的男性艾滋病患者接受了KS特异性治疗和/或抗逆转录病毒疗法。除了4名接受齐多夫定（ZDV）与另一种核苷类似物联合使用但未使用蛋白酶抑制剂的患者外，大多数患者接受了三联抗逆转录病毒疗法。在两份血样（治疗前后）中测量了血浆病毒载量和CD4 + T淋巴细胞数量。在所有处于KS I期的患者（5名）中发现完全缓解，II期的8名患者中有3名完全缓解，但III期和IV期的患者均未完全缓解。KS IV期的3名患者中有2名对治疗完全无反应。KS I期和II期的3名患者仅通过抗逆转录病毒疗法就实现了肉瘤的完全缓解,这表明抗逆转录病毒疗法和非KS特异性化疗可以成功控制KS。
