黑根霉NRRL 1477的11α和17α-孕酮羟化酶
The 11alpha and 17alpha-progesterone hydroxylases of Rhizopus nigricans NRRL 1477.
作者信息
Allam A M, el-Kady I A
出版信息
Acta Microbiol Pol A. 1975;7(1):41-4.
PMID:1114928
Abstract
Differential induction of cultures of Rhizopus nigricans indicated that hydroxylation of progesterone at the 11alpha- and 17alpha-positions is due to two separate enzymes. This is supported by the finding that 11alpha- and 17alpha-hydroxylating activities are separated by differential centrigufation of cell-free extracts. The feasibility of introducing a hydroxyl group at the 11alpha- or 17alpha-position of hydroxylated progesterone derivatives was tested.
摘要
黑根霉培养物的差异诱导表明，孕酮在11α-和17α-位的羟基化是由两种不同的酶引起的。这一观点得到以下发现的支持：通过对无细胞提取物进行差速离心可分离出11α-和17α-羟基化活性。测试了在羟基化孕酮衍生物的11α-或17α-位引入羟基的可行性。
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