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对性未成熟大鼠注射1-甲基-1-亚硝基脲后大鼠乳腺中发生的癌前病变和恶性病变的分类。

Classification of premalignant and malignant lesions developing in the rat mammary gland after injection of sexually immature rats with 1-methyl-1-nitrosourea.

作者信息

Thompson H J, Singh M, McGinley J

机构信息

Center for Nutrition in the Prevention of Disease, AMC Cancer Research Center, Lakewood, Colorado 80214, USA.

出版信息

J Mammary Gland Biol Neoplasia. 2000 Apr;5(2):201-10. doi: 10.1023/a:1026495322596.

DOI:10.1023/a:1026495322596
PMID:11149573
Abstract

Premalignant and malignant stages of mammary carcinogenesis can be rapidly induced by injecting female rats i.p. with 1-methyl-1-nitrosourea (MNU)3 at 21 days of age. In this paper, the characteristics of this model are briefly reviewed and the histology of the lesions induced is presented and compared to those that occur in humans. Malignant mammary lesions induced in rats injected with MNU at 21 days of age are compared with the lesions that develop when MNU is administered to 50-day-old female rats.

摘要

在21日龄雌性大鼠腹腔注射1-甲基-1-亚硝基脲（MNU）3可迅速诱导出乳腺癌发生的癌前和恶性阶段。本文简要回顾了该模型的特点，并展示了所诱导病变的组织学情况，并与人类发生的病变进行了比较。将21日龄注射MNU的大鼠诱导出的恶性乳腺病变与50日龄雌性大鼠注射MNU时发生的病变进行了比较。

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Classification of premalignant and malignant lesions developing in the rat mammary gland after injection of sexually immature rats with 1-methyl-1-nitrosourea.对性未成熟大鼠注射1-甲基-1-亚硝基脲后大鼠乳腺中发生的癌前病变和恶性病变的分类。
J Mammary Gland Biol Neoplasia. 2000 Apr;5(2):201-10. doi: 10.1023/a:1026495322596.
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Effect of energy restriction on the expression of cyclin D1 and p27 during premalignant and malignant stages of chemically induced mammary carcinogenesis.能量限制对化学诱导的乳腺癌发生癌前和恶性阶段细胞周期蛋白D1和p27表达的影响。
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Temporal sequence of mammary intraductal proliferations, ductal carcinomas in situ and adenocarcinomas induced by 1-methyl-1-nitrosourea in rats.1-甲基-1-亚硝基脲诱导大鼠乳腺导管内增生、导管原位癌和腺癌的时间顺序
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