Elhasid R, Ben Arush M W, Katz T, Gan Y, Shechter Y, Sami I, Postovsky S, Reisner Y, Rowe J M
Department of Pediatric Hemato-Oncology, Rambam Medical Center and Technion, Haifa, Israel.
Bone Marrow Transplant. 2000 Dec;26(11):1221-3. doi: 10.1038/sj.bmt.1702701.
A 10-year-old girl with Fanconi anemia and severe aplastic anemia underwent a haploidentical BMT from her mother due to lack of a matched family donor. T cell depletion was done by positive selection of CD34 cells with immunomagnetic beads. Due to graft rejection a second haploidentical BMT from the father was successfully undertaken. No immunosuppression was given after the transplant. Immunological reconstitution took approximately 6 months, with no GVHD or severe infections. Such a transplant, containing a large purified CD34 cell fraction with a minimal number of added T cells, should be considered as the treatment of choice for patients with Fanconi anemia if no HLA matched donor is available.
一名患有范可尼贫血和严重再生障碍性贫血的10岁女孩，因缺乏匹配的家族供体，接受了来自其母亲的单倍体相合骨髓移植。通过免疫磁珠对CD34细胞进行阳性选择来去除T细胞。由于发生移植物排斥，成功进行了来自父亲的第二次单倍体相合骨髓移植。移植后未给予免疫抑制治疗。免疫重建大约需要6个月，未发生移植物抗宿主病或严重感染。对于没有HLA匹配供体的范可尼贫血患者，如果没有HLA匹配供体，这种含有大量纯化CD34细胞成分且添加T细胞数量最少的移植应被视为首选治疗方法。
