Paulay K L, Damato A N
Am J Cardiol. 1975 Mar;35(3):370-5. doi: 10.1016/0002-9149(75)90029-6.
The effect of digoxin on sinus reentry was examined in 20 open chest mongrel dogs during infusion of digoxin at a rate of 2.5 mu g/kg per min. The extrinsic cardiac nerve supply was removed acutely in 10 dogs and was left intact in the remaining 10 dogs. Sinus nodal reentry was relatively unaffected by digoxin in 18 of 20 dogs. In these 18 dogs, digitalis toxicity developed before reentry was abolished and was manifested as increased atrial and ventricular automaticity in 14 and as advanced atrioventricular (A-V) block in four. In the remaining two dogs, sinus nodal reentry was relatively sensitive to digoxin and was abolished before toxicity became manifest as advanced A-V block. The knowledge of the relative insensitivity of sinus nodal reentry to digoxin, at least in this experimental model, contrasts with the previously reported sensitivity of sinus nodal reentry to quinidine, and may be important in the management of sinus nodal reentry in man.
在20只开胸杂种犬中，以每分钟2.5μg/kg的速率输注地高辛，研究地高辛对窦房结折返的影响。10只犬急性去除心脏外神经支配，其余10只犬保留完整的心脏外神经支配。20只犬中有18只犬的窦房结折返相对不受地高辛影响。在这18只犬中，洋地黄中毒在折返消除之前出现，表现为14只犬的心房和心室自律性增加，4只犬出现高度房室传导阻滞。在其余两只犬中，窦房结折返对地高辛相对敏感，在毒性表现为高度房室传导阻滞之前折返即被消除。至少在这个实验模型中，窦房结折返对地高辛相对不敏感这一认识与先前报道的窦房结对奎尼丁的敏感性形成对比，这可能对人类窦房结折返的治疗具有重要意义。
